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Ashwagandha Vs Ginseng, Rhodiola, Holy Basil, Maca, and Brahmi (Comprehensive Breakdown)

If you ever find yourself rifling through the scientific and historical literature on Ashwagandha, get ready for some unexpected astonishment. 

Ginseng Supplements

There really is just so much to be impressed by.

From its numerous health benefits, like supporting the immune system, treating anxiety, and relieving stress, to its foundational importance within Ayurvedic medicinal practices, (where ancient Hindu scholars wrote at length about the herbs curative powers); Ashwagandha is truly a gold standard nootropic herb.  


Ashwagandha Vs Brahmi

Ashwagandha VS Brahmi Illustration

Ashwagandha VS Ginseng

Ginseng Root illustration

Ashwagandha VS Holy Basil

Holy Basil illustration

Ashwagandha VS Maca

maca root animation

Ashwagandha VS Rhodiola

Rhodiola Rosea herb illustration for table of contents
ashwagandha inforgraph
Ashwagandha Overview Infograph

Ashwagandha Overview

In Hindi, the term Ashwagandha is a combination of the words ashva (horse) and gandha (smell) – the smell of a horse. 

This fairly bizarre name was coined from the odor that Ashwagandha’s roots emit; which apparently smells somewhat horse-like. 

I’ll take their word for it. 

Ashwagandha is an Adaptogen

A term that you will be running into A LOT if you spend any time researching ‘relaxing herbs’.

In the most basic sense, an adaptogen is any non-subversive, non-toxic substance that stabilizes psychological processes or reduces stress and anxiety in some way.

The term is thrown around without any universal agreement on precisely what it means.

Many of the herbs covered in this post are considered adaptogens: Holy Basil, Maca, Ginseng, Rhodiola – yet most affect completely different receptors and have very different chemical constituents.

Take Holy Basil (or Tulsi) for example: 

There is evidence that Holy Basil lowers metabolic stress through blood glucose; whereas an herb like Maca lowers stress and maintains hormonal balance by acting on the endocrine system

As I’m sure you know, these are VERY different functions that operate on very different bodily mechanisms, yet they’re thrown into the same adaptogen bucket. 

Keep in mind: 

Adaptogens vary greatly and many have different methods of functioning.  

With that being said, a question that we often receive on social media is which adaptogen is ‘better’? Ashwagandha or Brahmi? Ashwagandha or Ginseng? Should I purchase both? Can I take both at the same time? What is the best herb for anxiety? 

These are all fair questions, yet they don’t have a definitive answer.

There is no one herb or adaptogen that is functionally better than any other, but there are herbs with more scientific backing for specific health problems than others. 

And some of those health problems are obviously more important to get rid of than others (cancer vs hair loss for example).

So in this post, we outline the 5 most sought-after herbal attributes:

1.) Anti-Inflammatory

2.) Anti-Oxidant

3.) Neuro-Protective

4.) Anti-Anxiety

5.) Nootropic

to find out which adaptogen is best for each. 

So let’s get into it.  

Ashwagandha Benefits

Ashwagandha Benefits Infograph
Ashwagandha Chemical constituents

Ashwagandha’s main chemical constituents have been shown in studies to possess a large array of anti-oxidant and anti-inflammatory properties.

Especially Withaferin A, an alkaloid that seems to inhibit angiogenesis – angiogenesis being the main mechanism behind tumors turning malignant. 

Ashwagandha Grading Scale

best ashwagandha supplement

Ashwagandha Vs Brahmi

Ashwagandha VS Brahmi infograph

Much like Ashwagandha, Brahmi is used frequently in Ayurvedic medicine as a general tonic and a Rasayana – which is a Sanskrit term that means the lengthening of lifespan.

Throughout the history of Ayurveda, Brahmi was used for a whole host of ailments: like blood parasites, fevers, inflammation, joint pain, and skin problems, although, its most common use was as a nerve tonic. 

The word Brahmi is an Ayurvedic one, used for two different but very similar herbs:

Bacopa monnieri: A shrub that grows in Southern India and therefore is referred to as Brahmi by natives.

Bacopa monnieri

Centella asiatica: A perennial plant that grows in the wetlands of Asia; natives of Northern India call this herb Brahmi. 

Centella asiatica

Just to muddy the waters a bit more, there is another name given to Centella asiatica by westerners: Gotu Kola.

So just keep in mind:

both Bacopa monnieri and Centella asiatica are considered Brahmi, and Gotu Kola is simply the western name that has been thrown into the vernacular. 

Brahmi Benefits

Ayurvedic medicinal practitioners really hit a home run here.

Brahmi is beneficial across the board: Whether you’re looking for antioxidant, nootropic, anti-ulcer, anti-inflammatory, or anti-anxiety effects, Brahmi has you covered.

Antioxidant Banner

And I mean potent! 

  1.) Brahmi increases the activity of many endogenous antioxidant systems and directly lowers the amount of harmful free radicals in the body.

    2.) Researchers have shown that administered Brahmi extract helps protect against DNA damage in both animal and human cells.

3.) Brahmi was also found to increase the activity of superoxide dismutase in rat brains – significantly lowering overall stress.

Brahmi’s antioxidant chemical compounds include:

Both Luteolin and Cynaroside are powerful antioxidants that have been studied for their anti-tumor, anti-cancer, and anti-inflammatory effects.

Luteolin itself is such an effective antioxidant that it’s used frequently within the health community (especially the herbal health community) as a daily supplement.

1.) Those same antioxidant properties help the brain. An impressive study done in 2007 showed that Brahmi protects lipids and proteins from aluminum-induced oxidative stress in rabbits.

2.) Brahmi was also shown to mitigate the reduction of neurons in Alzheimer patients and increased the same patient’s scores at the Morris water maze test (a cognitive test).

Brahmi’s main neuroprotective compound:

Bacoside A

Bacoside A has been shown to prevent oxidative damage induced by smoking and is also sold as an individual supplement for daily use. 

1.) Brahmi has been shown to improve learning and memory in mice studies.

2.)  Brahmi significantly improved working memory and spatial working memory accuracy in this double blind placebo study.

3.) Brahmi was shown to improve performance on 9 out of 17 memory tests over a 12-week span. 

Brahmi’s main nootropic chemical compounds:

Both bacosides are responsible for the entirety of Brahmi’s cognitive improvements and have been individually studied and shown to improve overall mental retention capacity.

Inflammation is the immune system’s initial biological response to infections and irritation.

This response is strongly correlated with chronic diseases like diabetes, pulmonary disease, inflammatory bowel disease, and most cancers.

Luckily for us, there are MANY natural substances, especially within Ayurvedic medicine, which contain chemical compounds that help suppress inflammation and inhibit free radicals; Brahmi happens to be one of them. 

1.) Brahmi was found to suppress multiple inflammatory reactions while showing no gastric irritation.

2.) Brahmi was also found to carry out an anti-inflammatory activity against carrageenan-induced paw edema in rat populations.

3.) Brahmi was found to inhibit the production of Cox-2, an enzyme known for creating harmful lipids (like Thromboxane) that increase the overall likely-hood of stroke or cancer; along with antimicrobial properties.  

Brahmi’s anti-inflammatory chemical compounds include:

Although the entirety of Brahmi’s anti-inflammatory mechanisms isn’t entirely understood yet, most researchers believe that it’s the flavonoids along with Brahmi’s small amounts of betulic acid that do most of the heavy lifting. 

1.) A 2001 study found that 300 MG of Brahmi daily, reduced anxiety in rat populations significantly over a 12 weeks span

2.) Another study in 2013 found that participants who were administered Brahmi had overall lower levels of anxiety than the placebo group. 

Ashwagandha or Brahmi? 

Ashwagandha VS Brahmi grading report

As the grading tool above suggests, the scientific literature of today tells us that Brahmi is a better neuroprotective, anti-oxidant, and anti-inflammatory agent; whereas Ashwagandha is much better for Anxiety (and depression) problems, along with being an arguably better cognitive enhancer. 

Ashwagandha and Brahmi

Ashwagandha and Brahmi also work well together as a ‘stack’.

In Ayurvedic medicine, practitioners will oftentimes recommend combining the duo if a patient isn’t feeling the desired effects of one. 

The combination is entirely safe and has been used for hundreds of years. 

Brand Awareness:

Understand that some supplement manufacturers are much better than others. When purchasing Ashwagandha, I’ve had luck with Nutraherbals and Banyan Botanicals (I’m in no way affiliated with them).

No matter who you buy from, always make sure to sift through the reviews – especially the two and three-star reviews – as some companies notoriously pay for five.

I can vouch for all brands listed below, as I’ve personally tried each one.

But of course, feel free to @herbexaminer me on twitter if you have a bad experience with a certain brand. 

Ashwagandha VS Ginseng

Ashwagandha VS Ginseng Infograph

Few herbs have historical roots that dig as deep as Ginseng. Dating back to over five thousand years ago in Manchuria, China; Ginseng was considered a symbol of absolute harmony on planet earth and used extensively as one of the premier energy tonics within Chinese traditional medicine. 

[For more information on Ginseng, we have a full analytical article on Ginseng VS Ginger and other powerful herbs].  

There is tremendous confusion around which plants are and are not Ginseng. A good example is Eleutherococcus senticosus, a plant often referred to as Siberian Ginseng. The only problem? It’s not actually ginseng!

Panax Genus List

In order for an herb to be true Ginseng it must be from the genus ‘Panax’. Herbs like P. japonicus (Japanese Ginseng), and Pseudostellaria heterophylla (Prince Ginseng), are also not ginseng. 


Siberian Ginseng
Siberian Ginseng


Panax Ginseng
Panax Ginseng

 Ginseng Benefits

Ginseng is considered one of the most (monetarily) valuable herbs on earth – in large part due to its medicinal benefits and spiritual history. 

Ginseng Anti Stress Banner

1.) There are two glands in the brain that control most of the stress regulation in your body, the pituitary gland, and the adrenal gland. Ginseng directly affects these glands through activation of the hypothalamo-pituitary-adrenal axis.

2.) Another study found that the administration of ginseng to stressed mice lead to an overall significant anti-stress effect. 

Ginseng’s main chemical compounds for stress regulation:

These Ginsenosides are Ginseng’s most prized chemical constituents and are mostly responsible for Ginseng’s adaptogenic functions. 

Ginseng Cardiovascular Benefits Banner

1.) A study review published in 2012 found that the ginsenosides in Ginseng can increase nitric oxide production, increase blood circulation, and improve lipid profile in administered participants.

2.) Ginseng has potential cardiovascular benefits through mechanisms like anti-oxidation and improving lipid profiles.

 Ginseng or Ashwagandha?
Ashwagandha VS Ginseng

There haven’t been many published studies that show Ginseng as a great anti-anxiety or Neuro-protective agent, but the scientific consensus is strongly in favor of Ginseng’s strength as a nootropic and anti-oxidant. 

Ashwagandha on the other hand, once again, takes the prize as a superior anti-anxiety agent and an overall more powerful adaptogen. 

Red Ginseng VS White Ginseng Potency

If you want the most potent, anti-oxidant packed Ginseng go for red over white.

Red Ginseng is prepared by steaming raw Ginseng root for over 40 minutes, followed by a period of sun-drying that can last up for 15 days. The Ginsenosides (powerful antioxidant compounds unique to Ginseng) become MUCH more potent during this process; whereas white Ginseng is generally dried then sold. 

This study found that, as expected, Red Ginseng is more potent across the board as an antioxidant, and as an anti-inflammatory agent. 

So, as you can see, both herbs share similar flavonoids but clearly if you're looking for an herb with nootropic and anti-anxiety properties, Holy Basil doesn't offer much in that department - stick with Ashwagandha.

With that being said, Holy Basil shows more evidence of being a potent antioxidant and anti-inflammatory herb.

best holy basil supplement

Ashwagandha VS Maca

Ashwagandha VS Maca

The native people of Peru have used Maca (sometimes called Amazon Ginseng) root for centuries, largely for medicinal reasons. 

Along with being loaded with complex carbohydrates and vitamins B1, and B2, it contains a strong amino acid profile, as well as a bunch of different minerals like Calcium, Phosphorus, Zinc, and Iron. 

There are four main varieties of Maca powder: 

Cream Maca Powder -  Made from yellowish, creamy maca roots; this is by far the most popular variety of Maca. 

Red Maca Powder - Made from dark-purple maca roots. This variety is significantly rarer than the yellow root products and has a more sweet and sometimes even tangy taste to it. A few studies have shown that it may be the most nutritious out of all the varieties. 

Black Maca Powder - Dark grey Maca roots are the rarest (by far) and therefore the most valuable. This variety has been shown in studies to increase male libido more than any other. 

Gelatinized Maca Powder - Gelatinized Maca is created by simply boiling raw Maca root until most of the enclosed starch is removed; this is beneficial for those with sensitive stomachs.

Oh, and if you're a vegan, fear not! Contrary to the word gelatinized, there is actually no added gelatin in this product. 

Maca Benefits

Sexual Dysfunction banner

Maca happens to be one of the best-documented natural products for sexual dysfunction.

1.) A study published in 2008 found that Maca could alleviate SSRI-induced sexual dysfunction, along with having a beneficial effect on libido in humans.  

Anti Oxidant Banner.

1.) A study published in 2014 showed the Maca possesses significant anti-oxidant properties through its bio-active compounds. 

Main Chemical compound involved: 

Maca may improve sexual performance

1.) A 2002 study found Maca extract significantly improves sexual performance parameters in male rats.

Reduces depression banner

1.) A 2015 study found that Maca significantly reduces symptoms of depression in postmenopausal women. 

Ashwagandha or Maca?

Ashwagandha and maca grading scale

Although Maca certainly holds its own as an anti-oxidant, Ashwagandha is far superior for most of the graded conditions above. It's also worth mentioning that Maca is an aphrodisiac - Ashwagandha is not. 

maca supplements

Ashwagandha VS Rhodiola 

Ashwagandha VS Rhodiola

Rhodiola Rosea, often referred to as simply Rhodiola, is a well studied and extremely popular perennial plant used frequently within herbal and nootropic communities.

Researchers have traced its origins to the southwest area of China, where it has been used within Chinese Traditional Medicine for centuries.

Rhodiola's chemical constituents have been studied at length and shown to convey anti-stress and anti-fatigue benefits along with measurable improvements in memory and mental clarity.

Most of these beneficial compounds come from various tanniorganic acids, flavonoids, and tannins.

It's also worth noting that Rhodiola has been found to increase beta-endorphin (an endogenous opioid protein system) within humans without having to down-regulate receptors.

This essentially means that Rhodiola is unlikely to increase in user-tolerance over time. 

Rhodiola Benefits

1.) A study published in 2003 found that when administered to military cadets aged 19 to 21, Rhodiola significantly lowered overall levels of fatigue and stress.  

1.) A review of the literature surrounding Rhodiola (published in 2001), went over multiple studies that prove the herb's well regarded anti-fatigue benefits. 

1.) A 2000 study found that Rhodiola, administered to 56 physicians on night duty, significantly improved mental performance: this includes associative thinking, short-term memory and ability to concentrate.  

2.) Rhodiola extract, administered in rat populations, resulted in improved learning and memory after 24 hours

1.) A double-blind, placebo-controlled study published in 2009 found that levels of depression in Rhodiola administered males, age 18 - 70 years old, lowered significantly over the course of six weeks. 

Rhodiola's main anti-depressant chemical compounds: 

Ashwagandha or Rhodiola?

Ashwagandha or Rhodiola grading scale

Rhodiola is one of the few herbs that can really compete with Ashwagandha's medicinal benefits. 

It's loaded with numerous flavonoids and tannins which happen to be potent anti-oxidant and anti-inflammatory compounds.

Rhodiola best supplement

Nootropics are finicky - it takes some experimentation and commitment to find the perfect one for you. Looking at scientific research only goes so far; purchase a few and see which one(s) work the best with your unique body chemistry.